CRISPR/Cas9-mediated deletion of the Wiskott-Aldrich syndrome locus causes actin cytoskeleton disorganization in murine erythroleukemia cells

Wiskott-Aldrich syndrome (WAS) is a recessive X-linked inmmunodeficiency caused by loss-of-function mutations in the gene encoding the WAS protein (WASp). WASp plays an important role in the polymerization of the actin cytoskeleton in hematopoietic cells through activation of the Arp2/3 complex. In...

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Bibliographic Details

Published in:	PeerJ
Main Authors:	Vanessa Fernández-Calleja, María-José Fernández-Nestosa, Pablo Hernández, Jorge B. Schvartzman, Dora B. Krimer
Format:	Article
Language:	English
Published:	PeerJ Inc. 2019-01-01
Subjects:	Wiskott-Aldrich Erythroleukemia cells Actin cytoskeleton CRISPR/Cas9 Bruton tyrosine kinase
Online Access:	https://peerj.com/articles/6284.pdf