KDM6A Lysine Demethylase Directs Epigenetic Polarity of MDSCs during Murine Sepsis

Sepsis-induced myeloid-derived suppressor cells (MDSCs) increase mortality risk. We previously identified that long non-coding RNA Hotairm1 supports myeloid precursor shifts to Gr1+CD11b+ MDSCs during mouse sepsis. A major unanswered question is what molecular processes control Hotairm1 expression....

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Bibliographic Details

Published in:	Journal of Innate Immunity
Main Authors:	Isatou Bah, Tuqa Alkhateeb, Dima Youssef, Zhi Q. Yao, Charles E. McCall, Mohamed El Gazzar
Format:	Article
Language:	English
Published:	Karger Publishers 2021-07-01
Subjects:	sepsis myeloid-derived suppressor cell immune suppression hotairm1 epigenetics
Online Access:	https://www.karger.com/Article/FullText/517407