Effective Tumor Targeting by EphA2-Agonist-Biotin-Streptavidin Conjugates

We recently reported on a potent synthetic agent, 135H11, that selectively targets the receptor tyrosine kinase, EphA2. While 135H11 possesses a relatively high binding affinity for the ligand-binding domain of EphA2 (Kd~130 nM), receptor activation in the cell required the synthesis of dimeric vers...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Parima Udompholkul, Carlo Baggio, Luca Gambini, Yu Sun, Ming Zhao, Robert M. Hoffman, Maurizio Pellecchia
Format:	Article
Language:	English
Published:	MDPI AG 2021-06-01
Subjects:	agonistic EphA2 peptides streptavidin pancreatic cancer breast cancer cancer imaging orthotopic cancer models
Online Access:	https://www.mdpi.com/1420-3049/26/12/3687