African swine fever virus structural protein p17 inhibits IRF3 activation by recruiting host protein PR65A and inducing apoptotic degradation of STING

African swine fever virus (ASFV) is notoriously known for evolving strategies to modulate IFN signaling. Despite lots of efforts, the underlying mechanisms have remained incompletely understood. This study concerns the regulatory role of viral inner membrane protein p17. We found that the ASFV p17 s...

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Bibliographic Details

Published in:	Frontiers in Microbiology
Main Authors:	Shimin Wang, Zhiyong Xiang, Peng Gao, Yongning Zhang, Lei Zhou, Xinna Ge, Xin Guo, Jun Han, Hanchun Yang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-06-01
Subjects:	ASFV p17 IFN-β PR65A IFN apoptosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2024.1428233/full