The peroxisome counteracts oxidative stresses by suppressing catalase import via Pex14 phosphorylation

Most of peroxisomal matrix proteins including a hydrogen peroxide (H2O2)-decomposing enzyme, catalase, are imported in a peroxisome-targeting signal type-1 (PTS1)-dependent manner. However, little is known about regulation of the membrane-bound protein import machinery. Here, we report that Pex14, a...

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Bibliographic Details

Published in:	eLife
Main Authors:	Kanji Okumoto, Mahmoud El Shermely, Masanao Natsui, Hidetaka Kosako, Ryuichi Natsuyama, Toshihiro Marutani, Yukio Fujiki
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2020-08-01
Subjects:	catalase Pex14 peroxisomal protein import phosphorylation hydrogen peroxide oxidative stress
Online Access:	https://elifesciences.org/articles/55896