Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4 and protects against sepsis in mice

Sepsis progression is significantly associated with the disruption of gut eubiosis. However, the modulatory mechanisms of gut microbiota operating during sepsis are still unclear. Herein, we investigated how gut commensals impact sepsis development in a pre-clinical model. Cecal ligation and punctur...

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Bibliographic Details

Published in:	Acta Pharmaceutica Sinica B
Main Authors:	Dongping Li, Rongjuan Wei, Xianglong Zhang, Shenhai Gong, Meijuan Wan, Fangzhao Wang, Jiaxin Li, Meiling Chen, Ruofan Liu, Yantong Wan, Yinghao Hong, Zhenhua Zeng, Peng Gu, Zhang Wang, Kutty Selva Nandakumar, Yong Jiang, Hongwei Zhou, Peng Chen
Format:	Article
Language:	English
Published:	Elsevier 2024-07-01
Subjects:	Gut microbiota Sepsis Rhamnose SLC12A4 GTP-Rac1 GTP-Cdc42
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383524001060