Safety, Immunogenicity, and Protective Efficacy of a Chimeric A/B Live Attenuated Influenza Vaccine in a Mouse Model

Influenza A and B viruses cause significant morbidity and mortality worldwide. Current influenza vaccines are composed of three or four strains: A/H1N1, A/H3N2, and B (Victoria and Yamagata lineages). It is of great interest if immunization against both type A and B influenza viruses can be combined...

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Bibliographic Details

Published in:	Microorganisms
Main Authors:	Ekaterina Stepanova, Elena Krutikova, Pei-Fong Wong, Victoria Matyushenko, Ekaterina Bazhenova, Irina Isakova-Sivak, Larisa Rudenko
Format:	Article
Language:	English
Published:	MDPI AG 2021-01-01
Subjects:	live attenuated influenza vaccine LAIV influenza virus genome packaging reassortment influenza B virus
Online Access:	https://www.mdpi.com/2076-2607/9/2/259