Erythroid Differentiation and Heme Biosynthesis Are Dependent on a Shift in the Balance of Mitochondrial Fusion and Fission Dynamics

Erythropoiesis is the most robust cellular differentiation and proliferation system, with a production of ∼2 × 1011 cells per day. In this fine-tuned process, the hematopoietic stem cells (HSCs) generate erythroid progenitors, which proliferate and mature into erythrocytes. During erythropoiesis, mi...

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Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Alvaro M. Gonzalez-Ibanez, Lina M. Ruiz, Erik Jensen, Cesar A. Echeverria, Valentina Romero, Linsey Stiles, Orian S. Shirihai, Alvaro A. Elorza
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-11-01
Subjects:	mitochondria stem cell permeability transition pore erythropoiesis fission and fusion cell differentiation
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2020.592035/full