Integration of transcriptomics and metabolomics reveals the molecular mechanisms underlying the effect of nafamostat mesylate on rhabdomyolysis-induced acute kidney injury

Objective: To investigate the role and mechanisms of action of nafamostat mesylate (NM) in rhabdomyolysis-induced acute kidney injury (RIAKI).Methods: RIAKI rats were assigned into control group (CN), RIAKI group (RM), and NM intervention group (NM). Inflammatory cytokines and proenkephalin a 119–15...

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Published in:	Frontiers in Pharmacology
Main Authors:	Wenli Guo, Yu Wang, Yuxuan Wu, Jiang Liu, Ying Li, Jing Wang, Santao Ou, Weihua Wu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Subjects:	rhabdomyolysis acute kidney injury nafamostat mesylate transcriptomics metabolomics glutathione metabolism
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.931670/full