Hyperpolarized 13C pyruvate magnetic resonance spectroscopy for in vivo metabolic phenotyping of rat HCC
Abstract The in vivo assessment of tissue metabolism represents a novel strategy for the evaluation of oncologic disease. Hepatocellular carcinoma (HCC) is a high-prevalence, high-mortality tumor entity often discovered at a late stage. Recent evidence indicates that survival differences depend on m...
| 出版年: | Scientific Reports |
|---|---|
| 主要な著者: | Elisabeth Bliemsrieder, Georgios Kaissis, Martin Grashei, Geoffrey Topping, Jennifer Altomonte, Christian Hundshammer, Fabian Lohöfer, Irina Heid, Dominik Keim, Selamawit Gebrekidan, Marija Trajkovic-Arsic, Aline Winkelkotte, Katja Steiger, Roman Nawroth, Jens Siveke, Markus Schwaiger, Marcus Makowski, Franz Schilling, Rickmer Braren |
| フォーマット: | 論文 |
| 言語: | 英語 |
| 出版事項: |
Nature Portfolio
2021-01-01
|
| オンライン・アクセス: | https://doi.org/10.1038/s41598-020-80952-4 |
類似資料
Hyperpolarized <sup>13</sup>C Spectroscopy with Simple Slice-and-Frequency-Selective Excitation
著者:: Geoffrey J. Topping, 等
出版事項: (2021-01-01)
著者:: Geoffrey J. Topping, 等
出版事項: (2021-01-01)
Temperature dependent chemical shifts of pyruvate and lactate enable in vivo hyperpolarized 13C MRSI thermometry
著者:: Wolfgang Gottwald, 等
出版事項: (2025-05-01)
著者:: Wolfgang Gottwald, 等
出版事項: (2025-05-01)
13C MRI of hyperpolarized pyruvate at 120 µT
著者:: Nicolas Kempf, 等
出版事項: (2024-02-01)
著者:: Nicolas Kempf, 等
出版事項: (2024-02-01)
Simultaneous magnetic resonance imaging of pH, perfusion and renal filtration using hyperpolarized 13C-labelled Z-OMPD
著者:: Martin Grashei, 等
出版事項: (2023-08-01)
著者:: Martin Grashei, 等
出版事項: (2023-08-01)
Hyperpolarized [2–13C]pyruvate MR molecular imaging with whole brain coverage
著者:: Brian T. Chung, 等
出版事項: (2023-10-01)
著者:: Brian T. Chung, 等
出版事項: (2023-10-01)
Privacy: An Axiomatic Approach
著者:: Alexander Ziller, 等
出版事項: (2022-05-01)
著者:: Alexander Ziller, 等
出版事項: (2022-05-01)
pH Dependence of <i>T</i><sub>2</sub> for Hyperpolarizable <sup>13</sup>C-Labelled Small Molecules Enables Spatially Resolved pH Measurement by Magnetic Resonance Imaging
著者:: Martin Grashei, 等
出版事項: (2021-04-01)
著者:: Martin Grashei, 等
出版事項: (2021-04-01)
Regional quantification of metabolic liver function using hyperpolarized [1-13C] pyruvate MRI
著者:: Uffe Kjaergaard, 等
出版事項: (2025-03-01)
著者:: Uffe Kjaergaard, 等
出版事項: (2025-03-01)
Mutual-information based optimal experimental design for hyperpolarized $$^{13}$$ 13 C-pyruvate MRI
著者:: Prashant K. Jha, 等
出版事項: (2023-10-01)
著者:: Prashant K. Jha, 等
出版事項: (2023-10-01)
Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1–13C]pyruvate in vivo
著者:: Keilian MacCulloch, 等
出版事項: (2023-12-01)
著者:: Keilian MacCulloch, 等
出版事項: (2023-12-01)
Rapid in situ carbon-13 hyperpolarization and imaging of acetate and pyruvate esters without external polarizer
著者:: Obaid Mohiuddin, 等
出版事項: (2024-10-01)
著者:: Obaid Mohiuddin, 等
出版事項: (2024-10-01)
Detection of 3D Cardiac metabolism after injection of hyperpolarized [1-13C]pyruvate
著者:: Landini Luigi, 等
出版事項: (2011-02-01)
著者:: Landini Luigi, 等
出版事項: (2011-02-01)
Quantification of Abnormal Metabolism in Hypertrophic Cardiomyopathy Patients Using Hyperpolarized [1-13c]-pyruvate MRI
著者:: Avantika Sinha, MSc, 等
出版事項: (2024-01-01)
著者:: Avantika Sinha, MSc, 等
出版事項: (2024-01-01)
3D cardiac Chemical Shift Imaging of [1-13C] hyperpolarized acetate and pyruvate in pigs
著者:: Menichetti Luca, 等
出版事項: (2013-01-01)
著者:: Menichetti Luca, 等
出版事項: (2013-01-01)
Hyperpolarized [1-¹³C] pyruvate MRSI reveals a diet-dependent metabolic shift in ZSF1 rats
著者:: Karen Dos Santos, 等
出版事項: (2025-09-01)
著者:: Karen Dos Santos, 等
出版事項: (2025-09-01)
Dual hyperpolarized [1-13C]pyruvate and [13C]urea magnetic resonance imaging of prostate cancer
著者:: Ivan de Kouchkovsky, 等
出版事項: (2024-12-01)
著者:: Ivan de Kouchkovsky, 等
出版事項: (2024-12-01)
Myocardial metabolic flexibility following ketone infusion demonstrated by hyperpolarized [2-13C]pyruvate MRS in pigs
著者:: Sabrina Kahina Bech, 等
出版事項: (2025-02-01)
著者:: Sabrina Kahina Bech, 等
出版事項: (2025-02-01)
Hyperpolarized [1-13C]-pyruvate MRS evaluates immune potential and predicts response to radiotherapy in cervical cancer
著者:: Gigin Lin, 等
出版事項: (2024-04-01)
著者:: Gigin Lin, 等
出版事項: (2024-04-01)
Imaging Neurodegenerative Metabolism in Amyotrophic Lateral Sclerosis with Hyperpolarized [1-<sup>13</sup>C]pyruvate MRI
著者:: Nikolaj Bøgh, 等
出版事項: (2022-06-01)
著者:: Nikolaj Bøgh, 等
出版事項: (2022-06-01)
SABRE-hyperpolarization dynamics of [1-13C]pyruvate monitored by in situ zero- to ultra-low field NMR
著者:: Adam Ortmeier, 等
出版事項: (2024-06-01)
著者:: Adam Ortmeier, 等
出版事項: (2024-06-01)
MRI Application and Challenges of Hyperpolarized Carbon-13 Pyruvate in Translational and Clinical Cardiovascular Studies: A Literature Review
著者:: Francesca Frijia, 等
出版事項: (2024-05-01)
著者:: Francesca Frijia, 等
出版事項: (2024-05-01)
Metabolite-Specific Echo Planar Imaging for Preclinical Studies with Hyperpolarized <sup>13</sup>C-Pyruvate MRI
著者:: Sule I. Sahin, 等
出版事項: (2023-03-01)
著者:: Sule I. Sahin, 等
出版事項: (2023-03-01)
Metabolite-Specific Echo-Planar Imaging of Hyperpolarized [1-<sup>13</sup>C]Pyruvate at 4.7 T
著者:: Tyler Blazey, 等
出版事項: (2021-09-01)
著者:: Tyler Blazey, 等
出版事項: (2021-09-01)
Metabolic imaging with hyperpolarized [1-13C] pyruvate in patient-derived preclinical mouse models of breast cancer
著者:: Susana Ros, 等
出版事項: (2021-09-01)
著者:: Susana Ros, 等
出版事項: (2021-09-01)
Detection of increased pyruvate dehydrogenase flux in the human heart during adenosine stress test using hyperpolarized [1-13C]pyruvate cardiovascular magnetic resonance imaging
著者:: Steen Hylgaard Joergensen, 等
出版事項: (2022-06-01)
著者:: Steen Hylgaard Joergensen, 等
出版事項: (2022-06-01)
Preserving fairness and diagnostic accuracy in private large-scale AI models for medical imaging
著者:: Soroosh Tayebi Arasteh, 等
出版事項: (2024-03-01)
著者:: Soroosh Tayebi Arasteh, 等
出版事項: (2024-03-01)
Hyperpolarized [1-13C]pyruvate NMR spectroscopy reveals transition of tumor energy metabolism in microscale multicellular spheroids
著者:: Yoichi Takakusagi, 等
出版事項: (2025-06-01)
著者:: Yoichi Takakusagi, 等
出版事項: (2025-06-01)
Hyperpolarized [1-13C]pyruvate cardiovascular magnetic resonance imaging identifies metabolic phenotypes in patients with heart failure
著者:: Steen Hylgaard Joergensen, 等
出版事項: (2024-01-01)
著者:: Steen Hylgaard Joergensen, 等
出版事項: (2024-01-01)
Segmental analysis of cardiac metabolism by hyperpolarized [1-13C] pyruvate: an in-vivo 3D MRI study in pigs
著者:: Positano Vincenzo, 等
出版事項: (2012-02-01)
著者:: Positano Vincenzo, 等
出版事項: (2012-02-01)
Quantitative myocardial first-pass cardiovascular magnetic resonance perfusion imaging using hyperpolarized [1-13C] pyruvate
著者:: Maximilian Fuetterer, 等
出版事項: (2018-11-01)
著者:: Maximilian Fuetterer, 等
出版事項: (2018-11-01)
Initial Experience on Hyperpolarized [1-<sup>13</sup>C]Pyruvate MRI Multicenter Reproducibility—Are Multicenter Trials Feasible?
著者:: Nikolaj Bøgh, 等
出版事項: (2022-03-01)
著者:: Nikolaj Bøgh, 等
出版事項: (2022-03-01)
Developing a Method to Estimate the Downstream Metabolite Signals from Hyperpolarized [1-<sup>13</sup>C]Pyruvate
著者:: Ching-Yi Hsieh, 等
出版事項: (2022-07-01)
著者:: Ching-Yi Hsieh, 等
出版事項: (2022-07-01)
Differentially Private Guarantees for Analytics and Machine Learning on Graphs: A Survey of Results
著者:: Tamara T. Mueller, 等
出版事項: (2024-02-01)
著者:: Tamara T. Mueller, 等
出版事項: (2024-02-01)
ACLY facilitates alanine flux in the livers of db/db mice: a hyperpolarized [1-13C]pyruvate MRS study
著者:: Young-Suk Choi, 等
出版事項: (2025-10-01)
著者:: Young-Suk Choi, 等
出版事項: (2025-10-01)
[13C]bicarbonate labelled from hyperpolarized [1-13C]pyruvate is an in vivo marker of hepatic gluconeogenesis in fasted state
著者:: Emine Can, 等
出版事項: (2022-01-01)
著者:: Emine Can, 等
出版事項: (2022-01-01)
Enhancing Cancer Diagnosis with Real-Time Feedback: Tumor Metabolism through Hyperpolarized 1-<sup>13</sup>C Pyruvate MRSI
著者:: Gaurav Sharma, 等
出版事項: (2023-04-01)
著者:: Gaurav Sharma, 等
出版事項: (2023-04-01)
In Vivo Assessment of Metabolic Abnormality in Alport Syndrome Using Hyperpolarized [1-<sup>13</sup>C] Pyruvate MR Spectroscopic Imaging
著者:: Nguyen-Trong Nguyen, 等
出版事項: (2021-04-01)
著者:: Nguyen-Trong Nguyen, 等
出版事項: (2021-04-01)
Enhancing Metabolic Imaging of Energy Metabolism in Traumatic Brain Injury Using Hyperpolarized [1-<sup>13</sup>C]Pyruvate and Dichloroacetate
著者:: Stephen J. DeVience, 等
出版事項: (2021-05-01)
著者:: Stephen J. DeVience, 等
出版事項: (2021-05-01)
Hyperpolarized <sup>13</sup>C Magnetic Resonance Spectroscopic Imaging of Pyruvate Metabolism in Murine Breast Cancer Models of Different Metastatic Potential
著者:: Erin B. Macdonald, 等
出版事項: (2021-04-01)
著者:: Erin B. Macdonald, 等
出版事項: (2021-04-01)
Cardiac metabolism with hyperpolarized [1-<sup>13</sup>c]pyruvate: a feasibility study in mini-pig with a large dose injection
著者:: Recchia Fabio A, 等
出版事項: (2010-01-01)
著者:: Recchia Fabio A, 等
出版事項: (2010-01-01)
類似資料
-
Hyperpolarized <sup>13</sup>C Spectroscopy with Simple Slice-and-Frequency-Selective Excitation
著者:: Geoffrey J. Topping, 等
出版事項: (2021-01-01) -
Temperature dependent chemical shifts of pyruvate and lactate enable in vivo hyperpolarized 13C MRSI thermometry
著者:: Wolfgang Gottwald, 等
出版事項: (2025-05-01) -
13C MRI of hyperpolarized pyruvate at 120 µT
著者:: Nicolas Kempf, 等
出版事項: (2024-02-01) -
Simultaneous magnetic resonance imaging of pH, perfusion and renal filtration using hyperpolarized 13C-labelled Z-OMPD
著者:: Martin Grashei, 等
出版事項: (2023-08-01) -
Hyperpolarized [2–13C]pyruvate MR molecular imaging with whole brain coverage
著者:: Brian T. Chung, 等
出版事項: (2023-10-01)
