Structural polymorphism of the low-complexity C-terminal domain of TDP-43 amyloid aggregates revealed by solid-state NMR

Aberrant aggregation of the transactive response DNA-binding protein (TDP-43) is associated with several lethal neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal dementia. Cytoplasmic neuronal inclusions of TDP-43 are enriched in various fragments of the low-comp...

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Bibliographic Details

Published in:	Frontiers in Molecular Biosciences
Main Authors:	Jayakrishna Shenoy, Alons Lends, Mélanie Berbon, Muhammed Bilal, Nadia El Mammeri, Mathilde Bertoni, Ahmad Saad, Estelle Morvan, Axelle Grélard, Sophie Lecomte, François-Xavier Theillet, Alexander K. Buell, Brice Kauffmann, Birgit Habenstein, Antoine Loquet
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-03-01
Subjects:	TDP-43 amyotrophic lateral sclerosis frontotemporal dementia amyloid polymorphism solid-state NMR
Online Access:	https://www.frontiersin.org/articles/10.3389/fmolb.2023.1148302/full