Aptamer-assisted two-point immobilized agonist-bound angiotensin II type 1 receptor for a second-site modulator discovery

Summary: Methods of immobilized proteins are challenged by the way how to capture the proteins in their intact functional states. Here we present a two-point, high-specific method for the immobilization of conformationally specific angiotensin II type 1 receptor (AT1R) on amino-functionalized polyst...

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Bibliographic Details

Published in:	iScience
Main Authors:	Jiajun Liu, Ting Li, Ge Wang, Jiahuan Chen, Qingqing Yao, Qian Li, Xinfeng Zhao
Format:	Article
Language:	English
Published:	Elsevier 2022-11-01
Subjects:	Biochemistry biomolecules structural biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004222016339