The pre-mRNA splicing modulator pladienolide B inhibits Cryptococcus neoformans germination and growth

ABSTRACT Cryptococcus neoformans is an opportunistic fungal pathogen responsible for life-threatening infections, particularly in immunocompromised individuals. The limitations of current antifungal therapies due to toxicity and the emergence of resistance highlight the need for novel treatment stra...

Full description

Bibliographic Details
Published in:mSphere
Main Authors: Sierra L. Love, Megan C. McKeon, Henrik Vollmer, Joshua C. Paulson, Nanami Oshimura, Olivia Valentine, Sébastien C. Ortiz, Christina M. Hull, Aaron A. Hoskins
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Subjects:
C. neoformans
splicing
inhibitor
pre-mRNA
antifungal
Online Access:https://journals.asm.org/doi/10.1128/msphere.00248-25

Internet

https://journals.asm.org/doi/10.1128/msphere.00248-25

Similar Items