eIF2α-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons

Recreational drug use leads to compulsive substance abuse in some individuals. Studies on animal models of drug addiction indicate that persistent long-term potentiation (LTP) of excitatory synaptic transmission onto ventral tegmental area (VTA) dopamine (DA) neurons is a critical component of susta...

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Bibliographic Details
Published in:eLife
Main Authors: Andon N Placzek, Gonzalo Viana Di Prisco, Sanjeev Khatiwada, Martina Sgritta, Wei Huang, Krešimir Krnjević, Randal J Kaufman, John A Dani, Peter Walter, Mauro Costa-Mattioli
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-12-01
Subjects:
synaptic plasticity
psychostimulant abuse
protein synthesis
AMPAR
drug addiciton
Online Access:https://elifesciences.org/articles/17517

Internet

https://elifesciences.org/articles/17517

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