In Vivo Efficacy and Toxicity Studies of a Novel Antibacterial Agent: 14-O-[(2-Amino-1,3,4-thiadiazol-5-yl)Thioacetyl] Mutilin

A new pleuromutilin derivative with excellent antibacterial activity, 14-O-[(2-amino-1,3,4-thiadiazol-5-yl) thioacetyl] mutilin (ATTM), may serve as a possible lead compound for the development of antibacterial drugs. However, in vivo efficacy and toxicity evaluations of this compound have not been...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Chao Zhang, Yunpeng Yi, Jiongran Chen, Rensheng Xin, Zhen Yang, Zhiting Guo, Jianping Liang, Ruofeng Shang
Format:	Article
Language:	English
Published:	MDPI AG 2015-03-01
Subjects:	ATTM ED50 acute toxicity subchronic toxicity
Online Access:	http://www.mdpi.com/1420-3049/20/4/5299