Computer-Driven Development of an in Silico Tool for Finding Selective Histone Deacetylase 1 Inhibitors

Histone deacetylases (HDACs) are a class of epigenetic modulators overexpressed in numerous types of cancers. Consequently, HDAC inhibitors (HDACIs) have emerged as promising antineoplastic agents. Unfortunately, the most developed HDACIs suffer from poor selectivity towards a specific isoform, limi...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Hajar Sirous, Giuseppe Campiani, Simone Brogi, Vincenzo Calderone, Giulia Chemi
Format:	Article
Language:	English
Published:	MDPI AG 2020-04-01
Subjects:	3D-QSAR pharmacophore modeling ligand-based model HDACs isoform-selective histone deacetylase inhibitors aminophenylbenzamide
Online Access:	https://www.mdpi.com/1420-3049/25/8/1952