Preclinical development of an mRNA-based multiepitope immunotherapeutic for glioblastoma

Abstract Glioblastoma (GBM), an aggressive brain tumour associated with poor prognosis and high recurrence rate, has limited clinical treatment options. However, novel immunotherapeutics targeting over-presented epitopes of tumour-associated antigens (TAAs) represent a promising solution. Here we de...

Full description

Bibliographic Details

Published in:	Cancer Immunology, Immunotherapy
Main Authors:	Johannes Lutz, Randi K. Feist, Tim Sonntag, Esteban Peguero-Sánchez, Katharina Wolter, Ronja Bick, Jens Bauer, Juliane S. Walz, Regina Heidenreich
Format:	Article
Language:	English
Published:	Springer 2025-10-01
Subjects:	Glioblastoma Immunotherapy mRNA-based immunotherapeutic Cancer vaccine
Online Access:	https://doi.org/10.1007/s00262-025-04178-x