Functional impact of the eIF6 N106S mutation on ribosome biogenesis in wild type and Shwachman–Diamond syndrome cells

Abstract Background Eukaryotic initiation factor 6 (eIF6) is an essential regulator of ribosome biogenesis that prevents the premature association of the 60S and 40S ribosomal subunits. eIF6 eviction from nascent 60S particles, mediated by the ribosome biogenesis factors SBDS and EFL1, is required f...

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發表在:	Molecular Medicine
Main Authors:	Alexis Bertrand, Sarah Le Page, Vithura Pirabakaran, Laëtitia Kermasson, Erika Brunet, Jean Donadieu, Pierre-Emmanuel Gleizes, Marie-Françoise O’Donohue, Patrick Revy
格式:	Article
語言:	英语
出版:	BMC 2026-04-01
主題:	eIF6 Ribosome Shwachman-Diamond syndrome Ribosomal RNA biogenesis
在線閱讀:	https://doi.org/10.1186/s10020-026-01476-7