LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivity

Abstract Background WNT signaling plays a key role in postnatal bone formation. Individuals with gain-of-function mutations in the WNT co-receptor LRP5 exhibit increased lower-body fat mass and potentially enhanced glucose metabolism, alongside high bone mass. However, the mechanisms by which LRP5 r...

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Bibliographic Details

Published in:	Communications Medicine
Main Authors:	Nellie Y. Loh, Senthil K. Vasan, Daniel B. Rosoff, Emile Roberts, Andrea D. van Dam, Manu Verma, Daniel Phillips, Agata Wesolowska-Andersen, Matt J. Neville, Raymond Noordam, David W. Ray, Jonathan H. Tobias, Celia L. Gregson, Fredrik Karpe, Constantinos Christodoulides
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-02-01
Online Access:	https://doi.org/10.1038/s43856-025-00774-1