Vericiguat prevents high glucose-mediated impaired vascular smooth muscle cGMP production and vasorelaxation

Abstract Normal endothelial cell dependent vascular smooth muscle cell function is mediated by nitric oxide (NO), which stimulates soluble guanylyl cyclase (sGC) production of the second messenger cyclic guanosine monophosphate (cGMP) leading to increased protein kinase G (PKG) activity and vascular...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	David Polhemus, Diego Almodiel, Tarek Harb, Efthymios Ziogos, Nuria Amat-Codina, Mark Ranek, Lakshmi Santhanam, Gary Gerstenblith, Thorsten M. Leucker
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-02-01
Subjects:	Nitric oxide cGMP Vericiguat Vascular smooth muscle cell function Protein kinase G activity
Online Access:	https://doi.org/10.1038/s41598-025-88938-w