Cytoskeletal disarray increases arrhythmogenic vulnerability during sympathetic stimulation in a model of hypertrophic cardiomyopathy

Abstract Familial hypertrophic cardiomyopathy (FHC) patients are advised to avoid strenuous exercise due to increased risk of arrhythmias. Mice expressing the human FHC-causing mutation R403Q in the myosin heavy chain gene (MYH6) recapitulate the human phenotype, including cytoskeletal disarray and...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Henrietta Cserne Szappanos, Helena M. Viola, Danica W. Ito, Seakcheng Lim, Melissa Mangala, Mira Holliday, Samantha Barratt Ross, Christopher Semsarian, Adam Hill, Rose E. Dixon, Livia C. Hool
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-07-01
Online Access:	https://doi.org/10.1038/s41598-023-38296-2