Kv1.3 Channel Blockade Modulates the Effector Function of B Cells in Granulomatosis with Polyangiitis

B cells are central to the pathogenesis of granulomatosis with polyangiitis (GPA), exhibiting both (auto)antibody-dependent and -independent properties. Class-switched memory B cells in particular are a major source of pathogenic autoantibodies. These cells are characterized by high expression level...

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الحاوية / القاعدة:	Frontiers in Immunology
المؤلفون الرئيسيون:	Judith Land, Lucas L. Lintermans, Coen A. Stegeman, Ernesto J. Muñoz-Elías, Eric J. Tarcha, Shawn P. Iadonato, Peter Heeringa, Abraham Rutgers, Wayel H. Abdulahad
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Frontiers Media S.A. 2017-09-01
الموضوعات:	granulomatosis and polyangiitis B cells Kv1.3 potassium channels antineutrophil cytoplasmic antibody cytokines
الوصول للمادة أونلاين:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.01205/full