Polypharmacology‐Driven Discovery of ZAK‐I‐57: A Potent Multi‐Targeted Benzoxazinone Small Molecule for Hepatocellular Carcinoma Therapy

ABSTRACT Hepatocellular carcinoma (HCC) is a deadly disease characterized by a high mortality rate and resistance to conventional therapies, highlighting the need for novel therapeutic interventions. Given the multifaceted nature of HCC pathogenesis, a multitargeted and polypharmacological approach...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	MedComm
المؤلفون الرئيسيون:	Shakeel Ahmad Khan, Huihai Yang, Fan Ying, Chin Ngok Chu, Terence Kin Wah Lee
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Wiley 2025-08-01
الموضوعات:	benzoxazinone derivatives hepatocellular carcinoma multi‐targeted therapy polypharmacology tumor suppression
الوصول للمادة أونلاين:	https://doi.org/10.1002/mco2.70291