Polypharmacology‐Driven Discovery of ZAK‐I‐57: A Potent Multi‐Targeted Benzoxazinone Small Molecule for Hepatocellular Carcinoma Therapy

ABSTRACT Hepatocellular carcinoma (HCC) is a deadly disease characterized by a high mortality rate and resistance to conventional therapies, highlighting the need for novel therapeutic interventions. Given the multifaceted nature of HCC pathogenesis, a multitargeted and polypharmacological approach...

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出版年:	MedComm
主要な著者:	Shakeel Ahmad Khan, Huihai Yang, Fan Ying, Chin Ngok Chu, Terence Kin Wah Lee
フォーマット:	論文
言語:	英語
出版事項:	Wiley 2025-08-01
主題:	benzoxazinone derivatives hepatocellular carcinoma multi‐targeted therapy polypharmacology tumor suppression
オンライン･アクセス:	https://doi.org/10.1002/mco2.70291