Dynamics of SARS-CoV-2 immunity after vaccination and breakthrough infection in rituximab-treated rheumatoid arthritis patients: a prospective cohort study

BackgroundSARS-CoV-2 vaccination in rheumatoid arthritis (RA) patients treated with B cell-depleting drugs induced limited seroconversion but robust cellular response. We aimed to document specific T and B cell immunity in response to vaccine booster doses and breakthrough infection (BTI).MethodsWe...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Hassen Kared, Ingrid Jyssum, Amin Alirezaylavasani, Ingrid M. Egner, Trung The Tran, Lisa Tietze, Katrine Persgård Lund, Anne Therese Tveter, Sella A. Provan, Hilde Ørbo, Espen A. Haavardsholm, John Torgils Vaage, Kristin Jørgensen, Silje Watterdal Syversen, Fridtjof Lund-Johansen, Guro Løvik Goll, Ludvig A. Munthe
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-02-01
Subjects:	T cell B cell COVID-19 mRNA vaccination rheumatoid arthritis rituximab
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1296273/full