Transcriptional and Post-Transcriptional Polar Effects in Bacterial Gene Deletion Libraries

ABSTRACT Single-gene deletions can affect the expression levels of other genes in the same operon in bacterial genomes. Here, we used proteomics for 133 Escherichia coli gene deletion mutants and transcriptome sequencing (RNA-seq) data from 71 mutants to probe the extent of transcriptional and post-...

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Bibliographic Details
Published in:mSystems
Main Authors: André Mateus, Malay Shah, Johannes Hevler, Nils Kurzawa, Jacob Bobonis, Athanasios Typas, Mikhail M. Savitski
Format: Article
Language:English
Published: American Society for Microbiology 2021-10-01
Subjects:
Keio collection
knockout
polar effects
proteomics
single gene deletion
Online Access:https://journals.asm.org/doi/10.1128/msystems.00813-21

Internet

https://journals.asm.org/doi/10.1128/msystems.00813-21

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