High sperm DNA fragmentation: do we have robust evidence to support antioxidants and testicular sperm extraction to improve fertility outcomes? a narrative review

To date, infertility affects 10% to 15% of couples worldwide. A male factor is estimated to account for up to 50% of cases. Oral supplementation with antioxidants could be helpful to improve sperm quality by reducing oxidative damage. At the same time, there is a growing interest in the literature o...

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Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Massimo Romano, Federico Cirillo, Daria Spadaro, Andrea Busnelli, Stefano Castellano, Elena Albani, Paolo Emanuele Levi-Setti
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-10-01
Subjects:	sperm DNA fragmentation sperm dna damage reactive oxygen species (ROS) levels antioxidant Testicular sperm retrieval sperm DNA in testicular sperm
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2023.1150951/full