Protein disulfide-isomerase A4 confers glioblastoma angiogenesis promotion capacity and resistance to anti-angiogenic therapy

Abstract Introduction Increasing evidence has revealed the key activity of protein disulfide isomerase A4 (PDIA4) in the endoplasmic reticulum stress (ERS) response. However, the role of PDIA4 in regulating glioblastoma (GBM)-specific pro-angiogenesis is still unknown. Methods The expression and pro...

Full description

Bibliographic Details

Published in:	Journal of Experimental & Clinical Cancer Research
Main Authors:	Zewei Tu, Chong Wang, Qing Hu, Chuming Tao, Zhansheng Fang, Li Lin, Kunjian Lei, Min Luo, Yilei Sheng, Xiaoyan Long, Jingying Li, Lei Wu, Kai Huang, Xingen Zhu
Format:	Article
Language:	English
Published:	BMC 2023-03-01
Subjects:	Protein disulfide-isomerase A4 (PDIA4) Glioblastoma (GBM) Angiogenesis Endoplasmic reticulum stress (ERS) X-box binding protein 1 (XBP1)
Online Access:	https://doi.org/10.1186/s13046-023-02640-1