Activity of contezolid against methicillin-resistant Staphylococcus aureus in a rat model of foreign body osteomyelitis

ABSTRACT Contezolid has activity against methicillin-resistant Staphylococcus aureus (MRSA), a common cause of orthopedic infection. In a rat model of foreign body osteomyelitis, 1.3 log10 cfu/g bone and 0.5 log10 cfu/k-wire reduction in MRSA was found in tibiae (P = 0.0186) and K-wires, respectivel...

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Bibliographic Details

Published in:	Microbiology Spectrum
Main Authors:	Sebastian C. Herren, Melissa J. Karau, Christina Koscianski, Kerryl E. Greenwood-Quaintance, Jayawant N. Mandrekar, Wen Wang, Robin Patel
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-06-01
Subjects:	Methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis contezolid vancomycin rifampin rat
Online Access:	https://journals.asm.org/doi/10.1128/spectrum.02372-24