Platinum-based anticancer drugs-induced downregulation of myosin heavy chain isoforms in skeletal muscle of mouse

Cisplatin, a platinum-based anticancer drug used frequently in cancer treatment, causes skeletal muscle atrophy. It was predicted that the proteolytic pathway is enhanced as the mechanism of this atrophy. Therefore, we investigated whether a platinum-based anticancer drug affects the expression of t...

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Bibliographic Details

Published in:	Journal of Pharmacological Sciences
Main Authors:	Ken Sato, Yu Miyauchi, Xinran Xu, Risako Kon, Nobutomo Ikarashi, Yoshihiko Chiba, Tomoo Hosoe, Hiroyasu Sakai
Format:	Article
Language:	English
Published:	Elsevier 2023-07-01
Subjects:	Cisplatin Oxaliplatin Muscle atrophy Myosin heavy chain Myh2
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861323000300