Allosteric role of the citrate synthase homology domain of ATP citrate lyase

Abstract ATP citrate lyase (ACLY) is the predominant nucleocytosolic source of acetyl-CoA and is aberrantly regulated in many diseases making it an attractive therapeutic target. Structural studies of ACLY reveal a central homotetrameric core citrate synthase homology (CSH) module flanked by acyl-Co...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Xuepeng Wei, Kollin Schultz, Hannah L. Pepper, Emily Megill, Austin Vogt, Nathaniel W. Snyder, Ronen Marmorstein
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-04-01
Online Access:	https://doi.org/10.1038/s41467-023-37986-9