Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregates.

Mammalian prion structures and replication mechanisms are poorly understood. Most synthetic recombinant prion protein (rPrP) amyloids prepared without cofactors are non-infectious or much less infectious than bona fide tissue-derived PrPSc. This effect has been associated with differences in folding...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	PLoS Pathogens
المؤلفون الرئيسيون:	Bradley R Groveman, Gregory J Raymond, Katrina J Campbell, Brent Race, Lynne D Raymond, Andrew G Hughson, Christina D Orrú, Allison Kraus, Katie Phillips, Byron Caughey
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Public Library of Science (PLoS) 2017-09-01
الوصول للمادة أونلاين:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006623&type=printable