The genetic and clinical characteristics and effects of Canakinumab on cryopyrin-associated periodic syndrome: a large pediatric cohort study from China

Cryopyrin-associated periodic syndrome (CAPS) comprises a group of disorders characterized by recurrent bouts of systemic inflammation related to overactivation of inflammasome. So far, neither large cases of the correlation between genotype and phenotype nor treatment strategies have been clearly s...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Zhou Shu, Yue Zhang, Tongxin Han, Yan Li, Yurong Piao, Fei Sun, Jin Ma, Wenxiu Mo, Jiapeng Sun, Koon-Wing Chan, Wanling Yang, Yu-Lung Lau, Huawei Mao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-09-01
Subjects:	cryopyrin-associated periodic syndrome genotype and phenotype correlation novel mutation Canakinumab somatic mosaicism mutation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1267933/full