Adjuvant Cannabinoid Receptor Type 2 Agonist Modulates the Polarization of Microglia Towards a Non-Inflammatory Phenotype in Experimental Pneumococcal Meningitis

BackgroundMicroglia initiates and sustains the inflammatory reaction that drives the pathogenesis of pneumococcal meningitis. The expression of the G-protein cannabinoid receptor type 2 (CB2) in the brain is low, but is upregulated in glial cells during infection. Its activation down-regulates pro-i...

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Bibliographic Details

Published in:	Frontiers in Cellular and Infection Microbiology
Main Authors:	Steven D. Pan, Denis Grandgirard, Stephen L. Leib
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-11-01
Subjects:	bacterial meningitis microglia endocannabinoid system neuro-inflammation brain damage
Online Access:	https://www.frontiersin.org/articles/10.3389/fcimb.2020.588195/full