Trimethylamine N-oxide impairs β-cell function and glucose tolerance

Abstract β-Cell dysfunction and β-cell loss are hallmarks of type 2 diabetes (T2D). Here, we found that trimethylamine N-oxide (TMAO) at a similar concentration to that found in diabetes could directly decrease glucose-stimulated insulin secretion (GSIS) in MIN6 cells and primary islets from mice or...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Lijuan Kong, Qijin Zhao, Xiaojing Jiang, Jinping Hu, Qian Jiang, Li Sheng, Xiaohong Peng, Shusen Wang, Yibing Chen, Yanjun Wan, Shaocong Hou, Xingfeng Liu, Chunxiao Ma, Yan Li, Li Quan, Liangyi Chen, Bing Cui, Pingping Li
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-03-01
Online Access:	https://doi.org/10.1038/s41467-024-46829-0