The Fragile X Mental Retardation Protein Regulates Striatal Medium Spiny Neuron Synapse Density and Dendritic Spine Morphology

The fragile X mental retardation protein (FMRP), an RNA-binding protein that mediates the transport, stability, and translation of hundreds of brain RNAs, is critically involved in regulating synaptic function. Loss of FMRP, as in fragile X syndrome (FXS), is a leading monogenic cause of autism and...

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التفاصيل البيبلوغرافية
الحاوية / القاعدة:Frontiers in Molecular Neuroscience
المؤلفون الرئيسيون: Jessica L. Huebschman, Kitzia S. Corona, Yuhong Guo, Laura N. Smith
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Frontiers Media S.A. 2020-09-01
الموضوعات:
striatum
dendritic spine
RNA-binding proteins
FXS
synapse structure
morphology
الوصول للمادة أونلاين:https://www.frontiersin.org/article/10.3389/fnmol.2020.00161/full

الانترنت

https://www.frontiersin.org/article/10.3389/fnmol.2020.00161/full

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