Cytochrome c Release From Oridonin-Treated Apoptotic A375-S2 Cells Is Dependent on p53 and Extracellular Signal-Regulated Kinase Activation

We have reported that oridonin isolated from Rabdosia rubescens induces apoptosis of human melanoma A375-S2 cells within 12 h. In this study, TUNEL assay and flow cytometric analysis also indicate that one of the causes of A375-S2 cell death induced by oridonin was apoptosis. The cell death was prec...

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Bibliographic Details

Published in:	Journal of Pharmacological Sciences
Main Authors:	Chun-Ling Zhang, Li-Jun Wu, Hai-Jun Zuo, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima
Format:	Article
Language:	English
Published:	Elsevier 2004-01-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861319323576