Serotonin and psilocybin activate 5-HT1B receptors to suppress cortical signaling through the claustrum

Abstract Through its widespread reciprocal connections with the cerebral cortex, the claustrum is implicated in sleep and waking cortical network states. Yet, basic knowledge of neuromodulation in this structure is lacking. The claustrum is richly innervated by serotonergic fibers, expresses seroton...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Maxwell B. Madden, Chloe Schaefgen, Binita Vedak, Jian Kwon, Kiara S. Dresp Pedra, Samuel H. Sheats, Adam C. Puche, Steffen B. E. Wolff, Brian N. Mathur
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-08-01
Online Access:	https://doi.org/10.1038/s41467-025-62980-8