The Effect of Simvastatin on Gut Microbiota and Lipid Metabolism in Hyperlipidemic Rats Induced by a High-Fat Diet

The objective of this study was to investigate the effects of simvastatin (SIM) on lipid metabolism disorders and gut microbiota in high-fat diet-induced hyperlipidemic rats. The obtained results revealed that feeding rats with SIM (20 mg/kg/day) significantly decreased serum lipid level and inhibit...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Qing Zhang, Xiaoyun Fan, Rui Ye, Yuzhong Hu, Tingting Zheng, Rui Shi, Wenjian Cheng, Xucong Lv, Lijiao Chen, Peng Liang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-04-01
Subjects:	simvastatin hyperlipidemia lipid metabolism metabolomics gut microbiota
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2020.00522/full