Functional analysis of genes enriched in male reproductive organs: validation via fertility assessment of 14 knockout mouse lines

Tissue-restricted gene expression serves as a key indicator of functional importance within specific organs. Despite advances in high-throughput sequencing and genome editing over the past decade, this principle remains the gold standard for identifying candidate genes for functional studies. In rep...

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Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Kazumasa Takemoto, Katarzyna Kent, Kaori Nozawa, Shingo Tonai, Ahn H. Pham, Terumi Fujimoto, Thomas X. Garcia, Martin M. Matzuk, Masahito Ikawa, Keizo Tokuhiro
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2026-05-01
Subjects:	CRISPR/Cas9 epididymis evolutionary conservation gene redundancy male infertility null mutant mice
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2026.1851315/full