Derivation and Validation of a New Equation for Estimating Free Valproate Concentration in Critically Ill Adult Patients

IMPORTANCE:. Protein binding of valproate varies among ICU patients, altering the biologically active free valproate concentration (VPAC). Free VPAC is measured at few laboratories and is often discordant with total VPAC. Existing equations to predict free VPAC are either not validated or are inaccu...

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Bibliographic Details
Published in:Critical Care Explorations
Main Authors: Ji Tong Liu, PharmD, BCCCP, Caitlin S. Brown, PharmD, BCCCP, FCCM, Kristin C. Mara, MS, Richard R. Riker, MD, FCCM, Alejandro A. Rabinstein, MD, Gilles L. Fraser, PharmD, MCCM, Teresa L. May, DO, Kaitlin J. Armstrong, PharmD, David B. Seder, MD, FCCM, David J. Gagnon, PharmD, BCCCP, FCCM
Format: Article
Language:English
Published: Wolters Kluwer 2023-10-01
Online Access:http://journals.lww.com/10.1097/CCE.0000000000000987

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http://journals.lww.com/10.1097/CCE.0000000000000987

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