Extracellular vesicle‐packaged lncRNA from cancer‐associated fibroblasts promotes immune evasion by downregulating HLA‐A in pancreatic cancer

Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterised by immune evasion that contribute to poor prognosis. Cancer‐associated fibroblasts (CAFs) play a pivotal role in orchestrating the PDAC tumour microenvironment. We investigated the role of CAF‐derived extracellular vesicle (EV)‐packag...

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Bibliographic Details
Published in:Journal of Extracellular Vesicles
Main Authors: Hanming Yao, Chengzhi Huang, Jinmao Zou, Weiling Liang, Yue Zhao, Kege Yang, Ziyi Zhong, Shurui Zhou, Jiajia Li, Yaqing Li, Lishu Xu, Kaihong Huang, Guoda Lian
Format: Article
Language:English
Published: Wiley 2024-07-01
Subjects:
CAFs
engineered extracellular vesicles
immune evasion
lncRNA
MHC‐I
pancreatic cancer
Online Access:https://doi.org/10.1002/jev2.12484

Internet

https://doi.org/10.1002/jev2.12484

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