APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge

Summary: The E4 allele of Apolipoprotein E (APOE) is associated with both metabolic dysfunction and a heightened pro-inflammatory response: two findings that may be intrinsically linked through the concept of immunometabolism. Here, we combined bulk, single-cell, and spatial transcriptomics with cel...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Sangderk Lee, Nicholas A. Devanney, Lesley R. Golden, Cathryn T. Smith, James L. Schwartz, Adeline E. Walsh, Harrison A. Clarke, Danielle S. Goulding, Elizabeth J. Allenger, Gabriella Morillo-Segovia, Cassi M. Friday, Amy A. Gorman, Tara R. Hawkinson, Steven M. MacLean, Holden C. Williams, Ramon C. Sun, Josh M. Morganti, Lance A. Johnson
Format:	Article
Language:	English
Published:	Elsevier 2023-03-01
Subjects:	CP: Neuroscience
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124723002073