Tenecteplase versus alteplase for intravenous thrombolysis of acute ischemic stroke patients with large-vessel occlusion: a systematic review and meta-analysis

BackgroundTenecteplase (TNK) was found non-inferior to alteplase (ALT) for acute ischemic stroke (AIS). We sought to further elucidate the efficacy and safety of intravenous TNK versus ALT for AIS patients with large-vessel occlusion (LVO).MethodsWe systematically searched PubMed, Embase, Web of Sci...

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Bibliographic Details

Published in:	Frontiers in Neurology
Main Authors:	Beibei Yao, Xintong Wang, Yao Wu, Qing Zhu, Li Li, Xiaogang Tang, Minghua Wu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Subjects:	tenecteplase alteplase ischemic stroke large vessel occlusion meta-analysis
Online Access:	https://www.frontiersin.org/articles/10.3389/fneur.2025.1487711/full