N4-acetylcytidine modification of ITGB5 mRNA mediated by NAT10 promotes perineural invasion in pancreatic ductal adenocarcinoma

Abstract Background Perineural invasion (PNI) is a hallmark feature of pancreatic ductal adenocarcinoma (PDAC), which occurs at a high incidence and significantly contributes to PDAC lethality and poor survival. Despite its prevalence and association with poor prognosis, the molecular mechanisms und...

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出版年:	Journal of Experimental & Clinical Cancer Research
主要な著者:	Leyi Huang, Yanan Lu, Rihua He, Xiaofeng Guo, Jiajia Zhou, Zhiqiang Fu, Jingwen Li, Jianping Liu, Rufu Chen, Yu Zhou, Quanbo Zhou
フォーマット:	論文
言語:	英語
出版事項:	BMC 2025-03-01
主題:	Pancreatic ductal adenocarcinoma Perineural invasion RNA ac4C modification
オンライン･アクセス:	https://doi.org/10.1186/s13046-025-03362-2