Metformin elicits antitumour effect by modulation of the gut microbiota and rescues Fusobacterium nucleatum-induced colorectal tumourigenesis

Background: The effect of metformin on gut microbiota has been reported, but whether metformin can suppress colorectal cancer (CRC) by affecting gut microbiota composition and rescue F. nucleatum-induced tumourigenicity remains unclear. Methods: To identify microbiota associated with both CRC occurr...

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Bibliographic Details

Published in:	EBioMedicine
Main Authors:	Xiaowen Huang, Xialu Hong, Jilin Wang, Tiantian Sun, TaChung Yu, Yanan Yu, Jingyuan Fang, Hua Xiong
Format:	Article
Language:	English
Published:	Elsevier 2020-11-01
Subjects:	Colorectal cancer Metformin Microbiome Fusobacterium nucleatum
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396420304138