IGFBP2 alteration contributes to prostate cancer progression by modulating prostate stroma activation

Abstract Background Insulin-like growth factor (IGF) binding protein-2 (IGFBP2) is a secretory protein that modulate the activity of IGFs. It is highly expressed in various cancers such as prostate cancer (PCa), in which it may play a controversial role in tumor progression, however, the molecular m...

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Bibliographic Details

Published in:	Cell Communication and Signaling
Main Authors:	Mingguo Huang, Shintaro Narita, Hiromi Sato, Yuya Sekine, Mizuki Kobayashi, Soki Kashima, Ryohei Yamamoto, Atsushi Koizumi, Taketoshi Nara, Kazuyuki Numakura, Mitsuru Saito, Hiroshi Nanjo, Takayuki Ikezoe, Tomonori Habuchi
Format:	Article
Language:	English
Published:	BMC 2025-10-01
Subjects:	Insulin-like growth factor binding protein-2 IGFBP2 Prostate stromal cells Prostate cancer
Online Access:	https://doi.org/10.1186/s12964-025-02414-6