A new mechanism of action of sulodexide in diabetic nephropathy: inhibits heparanase-1 and prevents FGF-2-induced renal epithelial-mesenchymal transition

<p>Abstract</p> <p>Background</p> <p>Epithelial-mesenchymal transition of tubular cells is a widely recognized mechanism that sustains interstitial fibrosis in diabetic nephropathy (DN). The signaling of FGF-2, a growth factor involved in this mechanism, is regulated by...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Masola Valentina, Onisto Maurizio, Zaza Gianluigi, Lupo Antonio, Gambaro Giovanni
Format:	Article
Language:	English
Published:	BMC 2012-10-01
Subjects:	Diabetic nephropathy Epithelial-mesenchymal transition Fibrosis Heparanase-1 Sulodexide Tubular cells
Online Access:	http://www.translational-medicine.com/content/10/1/213