Allosteric inhibition of CRISPR-Cas9 by bacteriophage-derived peptides

Abstract Background CRISPR-Cas9 has been developed as a therapeutic agent for various infectious and genetic diseases. In many clinically relevant applications, constitutively active CRISPR-Cas9 is delivered into human cells without a temporal control system. Excessive and prolonged expression of CR...

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Bibliographic Details
Published in:Genome Biology
Main Authors: Yan-ru Cui, Shao-jie Wang, Jun Chen, Jie Li, Wenzhang Chen, Shuyue Wang, Bing Meng, Wei Zhu, Zhuhong Zhang, Bei Yang, Biao Jiang, Guang Yang, Peixiang Ma, Jia Liu
Format: Article
Language:English
Published: BMC 2020-02-01
Subjects:
CRISPR-Cas9
Inoviridae bacteriophage
Major coat protein G8P
Allosteric inhibition
Off-target activity
Online Access:http://link.springer.com/article/10.1186/s13059-020-01956-x

Internet

http://link.springer.com/article/10.1186/s13059-020-01956-x

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