The epigenetic regulators EP300/CREBBP represent promising therapeutic targets in MLL-rearranged acute myeloid leukemia

Abstract Acute myeloid leukemia (AML) with mixed-lineage leukemia (MLL) gene rearrangements (MLL-r) is an aggressive subtype of blood cancer with dismal prognosis, underscoring the urgent need for novel therapeutic strategies. E1A-binding protein (EP300) and CREB-binding protein (CREBBP) function as...

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Bibliographic Details

Published in:	Cell Death Discovery
Main Authors:	Wenqi Wu, Yanan Jiang, Donghui Xing, Yixin Zhai, Huimeng Sun, Xiang He, Kaiping Luo, Pengpeng Xu, Feng Pan, Guolei Dong, Guibing Ren, Zhigang Zhao
Format:	Article
Language:	English
Published:	Nature Publishing Group 2024-05-01
Online Access:	https://doi.org/10.1038/s41420-024-01940-5